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Article

Spontaneous trpY mutants and mutational analysis of the TrpY archaeal transcription regulator.

Journal of bacteriology - 1 Jun 2007

Cubonová L'ubomíra, Sandman Kathleen, Karr Elizabeth A, Cochran Andrew J, Reeve John N

Abstract excerpt

Over 90% of Methanothermobacter thermautotrophicus mutants isolated as spontaneously resistant to 5-methyl tryptophan had mutations in trpY. Most were single-base-pair substitutions that identified separate DNA- and tryptophan-binding regions in TrpY. In vivo and in vitro studies revealed that DNA binding was sufficient for TrpY repression of trpY transcription but that TrpY must bind DNA and tryptophan to...

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Identifiers

PMID: 17400746
DOI: 10.1128/JB.00164-07
PMCID: PMC1913389

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