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Article

High responsiveness of HLA-B57-restricted Gag-specific CD8+ T cells in vitro may contribute to the protective effect of HLA-B57 in HIV-infection.

European journal of immunology - 1 Jan 2005

Jansen Christine A, Kostense Stefan, Vandenberghe Kristin, Nanlohy Nening M, De Cuyper Iris M, Piriou Erwan, Manting Erik H, Miedema Frank, van Baarle Debbie

Abstract excerpt

HLA-B57 has been shown to be associated with long-term asymptomatic HIV-1 infection. To investigate the biological mechanism by which the HLA-B57 allele could protect from HIV-1 disease, we studied both the number of CD8(+) T cells as well as CD8(+) T cell responsiveness directed to different HIV-1 Gag peptides presented by HLA-A2, -B8 or -B57. T cells specific for the HLA-B57 peptide KAFSPEVIPMF responded more...

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PMID: 15593302
DOI: 10.1002/eji.200425487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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