Article
Effect of vitamin E supplementation on HDL function by haptoglobin genotype in type 1 diabetes: results from the HapE randomized crossover pilot trial.
Acta diabetologica - 1 Apr 2016
Costacou Tina, Levy Andrew P, Miller Rachel G, Snell-Bergeon Janet, Asleh Rabea, Farbstein Dan, Fickley Catherine E, Pambianco Georgia, de la Vega Rona, Evans Rhobert W, Orchard Trevor J
Abstract excerpt
AIMS: Haptoglobin (Hp) genotype 2-2 increases cardiovascular diabetes complications. In type 2 diabetes, α-tocopherol was shown to lower cardiovascular risk in Hp 2-2, potentially through HDL function improvements. Similar type 1 diabetes data are lacking. We conducted a randomized crossover pilot of α-tocopherol supplementation on HDL function [i.e., cholesterol efflux (CE) and HDL-associated lipid peroxides...
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