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The haptoglobin 2-2 genotype is associated with carotid atherosclerosis in 64-year old women with established diabetes.

Clinica chimica acta; international journal of clinical chemistry - 2 Apr 2010

Ryndel Mikael, Behre Carl Johan, Brohall Gerhard, Prahl Ulrica, Schmidt Caroline, Bergström Göran, Fagerberg Björn, Olson Fredrik J

Abstract excerpt

BACKGROUND: Haptoglobin polymorphism generates three common human genotypes: Hp1-1, Hp2-1 and Hp2-2. Among subjects with diabetes, Hp2-2 is associated with an elevated risk to develop cardiovascular disease. The impact of haptoglobin genotype on subclinical carotid atherosclerosis is not known. We hypothesized that Hp2-2 was associated with increased occurrence of carotid atherosclerosis in subjects with...

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PMID: 20064496
DOI: 10.1016/j.cca.2009.12.025

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