Article
Conversion of premalignant human cells to tumorigenic cells by methylmethane sulfonate and methylnitronitrosoguanidine.
Cell biology and toxicology - 1 Jan 2000
Milo G E, Shuler C F, Stoner G, Chen J C
Abstract excerpt
Nine human tumor cell lines derived from both epithelial and mesenchymal tumors exhibited either an anchorage-independent growth non-tumorigenic phenotype or an anchorage-independent tumorigenic phenotype. Transformed epithelial cell lines with the non-tumorigenic phenotype could be converted to...
Topics
- Animals
- Carcinoma, Small Cell
- Carcinoma, Squamous Cell
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Chondrosarcoma
- Fibrosarcoma
- Humans
- Male
- Methyl Methanesulfonate
- Methylnitronitrosoguanidine
- Mice
- Mice, Nude
- Osteosarcoma
- Phenotype
- Rhabdomyosarcoma
- Tumor Cells, Cultured