Article
Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2005
Huang Wen-Yi, Chatterjee Nilanjan, Chanock Stephen, Dean Michael, Yeager Meredith, Schoen Robert E, Hou Li-Fang, Berndt Sonja I, Yadavalli Sunita, Johnson Christine C, Hayes Richard B
Abstract excerpt
Cigarette smoking is a risk factor for colorectal adenoma, a precursor of colorectal cancer. Microsomal epoxide hydrolase (EPHX1) metabolizes polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke. Nonsynonymous variants of EPHX1 at Tyr(113)His (exon 3) and His(139)Arg (exon 4) are associated, respectively, with low ((113)His) and high ((139)Arg) predicted activity. Among participants randomized...
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