Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom).

Cancer causes & control : CCC - 1 Aug 2006

Mitrou Panagiota N, Watson Mark A, Loktionov Alexandre S, Cardwell Christopher, Gunter Marc J, Atkin Wendy S, Macklin Christopher P, Cecil Tom, Bishop Timothy D, Primrose John, Bingham Sheila A

Abstract excerpt

OBJECTIVE: The purpose of this study was to further evaluate the role of low activity MTHFR variants as well as to explore interactive effects between alcoholic drink consumption and MTHFR variants and risk of distal colorectal adenomatous polyps. METHODS: We examined the relationship between MTHFR C677T and A1298C gene polymorphisms and risk of distal adenomas in one of the largest case control studies of 946...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Adenomatous Polyps

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Alcohol Drinking

Share to Case-Control Studies

Share to Colorectal Neoplasms

Share to Gene Frequency

Share to Mass Screening

Share to Risk Factors

Source

Identifiers

PMID: 16783607
DOI: 10.1007/s10552-006-0016-8

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom).PMID 16783607Read ↗

Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer.Semantic proximity Read ↗

Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction?Semantic proximity Read ↗

Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study.Semantic proximity Read ↗

Lack of association between the C677T MTHFR polymorphism and colorectal hyperplastic polyps.Semantic proximity Read ↗

Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.Semantic proximity Read ↗

No association between cytochrome P450 and glutathione S-transferase gene polymorphisms and risk of colorectal adenoma: results from the UK Flexible Sigmoidoscopy Screening Trial.Semantic proximity Read ↗

DNA methyltransferase and alcohol dehydrogenase: gene-nutrient interactions in relation to risk of colorectal polyps.Semantic proximity Read ↗

Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer: a meta-analysis.Semantic proximity Read ↗

Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS Study.Semantic proximity Read ↗

A prospective study of genetic polymorphisms in the cytochrome P-450 2C9 enzyme and the risk for distal colorectal adenoma.Semantic proximity Read ↗

The methylenetetrahydrofolate reductase 677C-->T polymorphism and distal colorectal adenoma risk.Semantic proximity Read ↗

[A case-control study on the polymorphisms of methylenetetrahydrofolate reductases, drinking interaction and susceptibility in colorectal cancer].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.