Article
Characterization and sequence analyses of antibody-selected antigenic variants of herpes simplex virus show a conformationally complex epitope on glycoprotein H.
Journal of virology - 1 May 1991
Gompels U A, Carss A L, Saxby C, Hancock D C, Forrester A, Minson A C
Abstract excerpt
Thirteen antigenic variants of herpes simplex virus which were resistant to neutralization by monoclonal antibody 52S or LP11 were isolated and characterized. The antibodies in the absence of complement potently neutralize infectivity of wild-type virus as well as inhibit the transfer of virus fr...
Topics
- Amino Acids
- Animals
- Antibodies, Monoclonal
- Antibodies, Viral
- Antigenic Variation
- Antigens, Viral
- Cell Line
- Epitopes
- Genes, Viral
- Mutation
- Neutralization Tests
- Precipitin Tests
- Protein Conformation
- Simplexvirus
- Species Specificity