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Article

Phenotypic and genotypic characterization of influenza virus mutants selected with the sialidase fusion protein DAS181.

The Journal of antimicrobial chemotherapy - 1 Jan 2011

Triana-Baltzer Gallen B, Sanders Rebecca L, Hedlund Maria, Jensen Kellie A, Aschenbrenner Laura M, Larson Jeffrey L, Fang Fang

Abstract excerpt

BACKGROUND: influenza viruses (IFVs) frequently achieve resistance to antiviral drugs, necessitating the development of compounds with novel mechanisms of action. DAS181 (Fludase), a sialidase fusion protein, may have a reduced potential for generating drug resistance due to its novel host-target...

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Identifiers

PMID: 21097900
DOI: 10.1093/jac/dkq387
PMCID: PMC3001847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21097900-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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