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Article

Loss of the N-linked glycan at residue 173 of human parainfluenza virus type 1 hemagglutinin-neuraminidase exposes a second receptor-binding site.

Journal of virology - 1 Sept 2008

Alymova Irina V, Taylor Garry, Mishin Vasiliy P, Watanabe Makiko, Murti K Gopal, Boyd Kelli, Chand Pooran, Babu Y Sudhakara, Portner Allen

Abstract excerpt

BCX 2798 (4-azido-5-isobutyrylamino-2,3-didehydro-2,3,4,5-tetradeoxy-d-glycero-d-galacto-2-nonulopyranosic acid) effectively inhibited the activities of the hemagglutinin-neuraminidase (HN) of human parainfluenza viruses (hPIV) in vitro and protected mice from lethal infection with a recombinant Sendai virus whose HN was replaced with that of hPIV-1 (rSeV[hPIV-1HN]) (I. V. Alymova, G. Taylor, T. Takimoto, T. H....

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Identifiers

PMID: 18579600
DOI: 10.1128/JVI.00474-08
PMCID: PMC2519627

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Source receipt: pubmed, retrieved 7 Sept 2026.

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