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Article

Three ubiquitin conjugation sites in the amino terminus of the dopamine transporter mediate protein kinase C-dependent endocytosis of the transporter.

Molecular biology of the cell - 1 Jan 2007

Miranda Manuel, Dionne Kalen R, Sorkina Tatiana, Sorkin Alexander

Abstract excerpt

Dopamine levels in the brain are controlled by the plasma membrane dopamine transporter (DAT). The amount of DAT at the cell surface is determined by the relative rates of its internalization and recycling. Activation of protein kinase C (PKC) leads to acceleration of DAT endocytosis. We have rec...

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Identifiers

PMID: 17079728
DOI: 10.1091/mbc.e06-08-0704
PMCID: PMC1751334

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17079728-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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