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Article

The special phenotypic characteristics of Dummerstorf superfertile mouse lines could depend on the expression levels of IGF-axis genes.

Reproductive biology - 1 Jun 2025

Calanni-Pileri Michela, Weitzel Joachim M, Hoeflich Andreas, Langhammer Martina, Michaelis Marten

Abstract excerpt

To date, animal models with reproductive phenotypes are knockout or transgenic and typically exhibit reduced fertility or infertility. This limits research to studying single-gene effects or loss of fertility. By contrast, Dummerstorf high-fertility mouse lines 1 and 2 (FL1 and FL2) are two unique outbred selection models that demonstrate exceptional reproductive performance. After approximately 50 years of...

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Identifiers

PMID: 40158446
DOI: 10.1016/j.repbio.2025.101012

Genes

IGFBP4
IGFBP2

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