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Article

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors.

Proceedings of the National Academy of Sciences of the United States of America - 7 Nov 2006

Taly Antoine, Corringer Pierre-Jean, Grutter Thomas, Prado de Carvalho Lia, Karplus Martin, Changeux Jean-Pierre

Abstract excerpt

Nicotinic acetylcholine receptors (nAChR) are pentameric ligand-gated ion channels composed of subunits that consist of an extracellular domain that carries the ligand-binding site and a distinct ion-pore domain. Signal transduction results from the allosteric coupling between the two domains: the distance from the binding site to the gate of the pore domain is 50 A. Normal mode analysis with a C(alpha) Gaussian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17077146
DOI: 10.1073/pnas.0607477103
PMCID: PMC1629088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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