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Article

Myasthenic nicotinic receptor mutant interpreted in terms of the allosteric model.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie - 1 Dec 1997

Edelstein S J, Schaad O, Changeux J P

Abstract excerpt

An extended Monod-Wyman-Changeux allosteric-type model is applied to human muscle nicotinic acetylcholine receptors expressed in HEK cells, for both the normal form and the high-affinity human myasthenic mutant, epsilon T264P. The model is based on a concerted transition between the basal (resting) B state and the active (open-channel) A state, with the equilibrium in the absence of ligand determined by the...

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Identifiers

PMID: 9587473
DOI: 10.1016/s0764-4469(97)82468-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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