Article
A7DB: a relational database for mutational, physiological and pharmacological data related to the alpha7 nicotinic acetylcholine receptor.
BMC neuroscience - 20 Jan 2005
Buckingham Steven D, Pym Luanda, Jones Andrew K, Brown Laurence, Sansom Mark S P, Sattelle David B, Biggin Philip C
Abstract excerpt
BACKGROUND: Nicotinic acetylcholine receptors (nAChRs) are pentameric proteins that are important drug targets for a variety of diseases including Alzheimer's, schizophrenia and various forms of epilepsy. One of the most intensively studied nAChR subunits in recent years has been alpha7. This subunit can form functional homomeric pentamers (alpha7)5, which can make interpretation of physiological and structural...
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