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Article

Phosphomimetic cardiac myosin-binding protein C partially rescues a cardiomyopathy phenotype in murine engineered heart tissue.

Scientific reports - 3 Dec 2019

Dutsch Alexander, Wijnker Paul J M, Schlossarek Saskia, Friedrich Felix W, Krämer Elisabeth, Braren Ingke, Hirt Marc N, Brenière-Letuffe David, Rhoden Alexandra, Mannhardt Ingra, Eschenhagen Thomas, Carrier Lucie, Mearini Giulia

Abstract excerpt

Phosphorylation of cardiac myosin-binding protein C (cMyBP-C), encoded by MYBPC3, increases the availability of myosin heads for interaction with actin thus enhancing contraction. cMyBP-C phosphorylation level is lower in septal myectomies of patients with hypertrophic cardiomyopathy (HCM) than in non-failing hearts. Here we compared the effect of phosphomimetic (D282) and wild-type (S282) cMyBP-C gene transfer...

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Identifiers

PMID: 31796859
DOI: 10.1038/s41598-019-54665-2
PMCID: PMC6890639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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