Article
Cardiac myosin binding protein C phosphorylation in cardiac disease.
Journal of muscle research and cell motility - 1 May 2012
Kuster Diederik W D, Bawazeer Amira Cholid, Zaremba Ruud, Goebel Max, Boontje Nicky M, van der Velden Jolanda
Abstract excerpt
Perturbations in sarcomeric function may in part underlie systolic and diastolic dysfunction of the failing heart. Sarcomeric dysfunction has been ascribed to changes in phosphorylation status of sarcomeric proteins caused by an altered balance between intracellular kinases and phosphatases during the development of cardiac disease. In the present review we discuss changes in phosphorylation of the thick filament...
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