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Article

Mechanisms of protein-folding diseases at a glance.

Disease models & mechanisms - 1 Jan 2014

Valastyan Julie S, Lindquist Susan

Abstract excerpt

For a protein to function appropriately, it must first achieve its proper conformation and location within the crowded environment inside the cell. Multiple chaperone systems are required to fold proteins correctly. In addition, degradation pathways participate by destroying improperly folded proteins. The intricacy of this multisystem process provides many opportunities for error. Furthermore, mutations cause...

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Identifiers

PMID: 24396149
DOI: 10.1242/dmm.013474
PMCID: PMC3882043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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