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Article

Immortalization of growth factor-dependent mouse splenic macrophages derived from cloned progenitors.

Journal of immunological methods - 1 Mar 1991

Wilson C M, Gatewood J W, McCormack J M, Walker W S

Abstract excerpt

We describe a nonviral transformation strategy for the establishment of permanent cell lines derived from the progeny of individual mouse splenic macrophage (M phi) progenitors. These colony stimulating factor-1 (CSF-1)-dependent cell lines possess many features of mature M phi s, including antibody-dependent phagocytic and cellular cytotoxic activities, ability to secrete lysozyme, and expression of the Mac-1...

Topics

Animals
Cell Division
Cell Line, Transformed
Macrophage Colony-Stimulating Factor
Macrophages
Mice
Mice, Inbred Strains
Muramidase
Phenotype
RNA-Directed DNA Polymerase
Receptor, Macrophage Colony-Stimulating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spleen

Stem Cells

Source

Identifiers

PMID: 1707081
DOI: 10.1016/0022-1759(91)90389-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1707081-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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