Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immortalization of macrophages from mouse bone marrow and fetal liver.

Experimental cell research - 1 Jun 1990

Gandino L, Varesio L

Abstract excerpt

Fresh bone marrow (BM)-derived cells infected with the J2 recombinant retrovirus (carrying v-myc and v-raf/mil oncogenes) grow as immortal cell lines belonging to the monocytic lineage. BM cells cultured for 24 h in conventional medium are no longer able to grow following infection with the J2 vi...

Topics

Animals
Bone Marrow
Bone Marrow Cells
Cell Division
Cell Line
Cells, Cultured
Colony-Stimulating Factors
Concanavalin A
Growth Substances
Liver
Macrophage Colony-Stimulating Factor
Macrophages
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Phenotype

RNA, Viral

Retroviridae

Spleen

Source

Identifiers

PMID: 2185941
DOI: 10.1016/0014-4827(90)90159-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2185941-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immortalization of macrophages from mouse bone marrow and fetal liver.PMID 2185941Read ↗

In vivo immortalization of murine peritoneal macrophages: a new rapid and efficient method for obtaining macrophage cell lines.Semantic proximity Read ↗

Gene therapy of Csf2ra deficiency in mouse fetal monocyte precursors restores alveolar macrophage development and functionSemantic proximity Read ↗

New tools for investigating macrophage differentiation.Semantic proximity Read ↗

Ectopic expression of transcription factor NF-E2 alters the phenotype of erythroid and monoblastoid cells.Semantic proximity Read ↗

Immortalization of growth factor-dependent mouse splenic macrophages derived from cloned progenitors.Semantic proximity Read ↗

Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system.Semantic proximity Read ↗

Generation and differentiation potential of retrovirus-immortalized mature murine B cells.Semantic proximity Read ↗

Isolation and immortalization of macrophages derived from fetal porcine small intestine and their susceptibility to porcine viral pathogen infectionsSemantic proximity Read ↗

Derivation of mixed phenotype cell lines with ras-myc- and raf-myc-containing retroviral vectors after infection of murine long-term bone marrow cultures.Semantic proximity Read ↗

Macrophage cell lines use CD81 in cell growth regulation.Semantic proximity Read ↗

Macrophage migration inhibitory factor deficiency is associated with altered cell growth and reduced susceptibility to Ras-mediated transformation.Semantic proximity Read ↗

Induction of proliferation or transformation of neuroretina cells by the mil and myc viral oncogenes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.