Article
Pharmacogenomic interaction between the Haptoglobin genotype and vitamin E on atherosclerotic plaque progression and stability.
Atherosclerosis - 1 Mar 2015
Veiner Hilla-Lee, Gorbatov Rostic, Vardi Moshe, Doros Gheorghe, Miller-Lotan Rachel, Zohar Yaniv, Sabo Edmond, Asleh Rabea, Levy Nina S, Goldfarb Levi J, Berk Thomas A, Haas Tali, Shalom Hadar, Suss-Toby Edith, Kam Adi, Kaplan Marielle, Tamir Ronit, Ziskind Anna, Levy Andrew P
Abstract excerpt
OBJECTIVE: Homozygosity for a 1.7 kb intragenic duplication of the Haptoglobin (Hp) gene (Hp 2-2 genotype), present in 36% of the population, has been associated with a 2-3 fold increased incidence of atherothrombosis in individuals with Diabetes (DM) in 10 longitudinal studies compared to DM individuals not homozygous for this duplication (Hp 1-1/2-1). The increased CVD risk associated with the Hp 2-2 genotype...
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