Article
Resistance of HIV-1 to AZT might also involve the cellular expression of multidrug resistance P-glycoprotein.
AIDS research and human retroviruses - 1 Oct 1992
Antonelli G, Turriziani O, Cianfriglia M, Riva E, Dong G, Fattorossi A, Dianzani F
Abstract excerpt
Resistance of tumor cells to the antigrowth activity of several cytotoxic compounds has been associated with the expression of the so-called multidrug resistance protein or P-glycoprotein. This article addresses the question whether the expression of such protein could also affect the sensitivity of HIV to AZT. Our data indicate that this possibility does exist. In fact, multidrug-resistant CEM VBL100 cells,...
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