Article
Safety and efficacy of lamivudine-zidovudine combination therapy in zidovudine-experienced patients. A randomized controlled comparison with zidovudine monotherapy. Lamivudine European HIV Working Group.
JAMA - 10 Jul 1996
Staszewski S, Loveday C, Picazo J J, Dellarnonica P, Skinhøj P, Johnson M A, Danner S A, Harrigan P R, Hill A M, Verity L, McDade H
Abstract excerpt
OBJECTIVE: To compare the safety and efficacy of 2 doses of lamivudine given in combination with zidovudine with continued zidovudine monotherapy. DESIGN: Double-blind, randomized, multicenter, comparative trial of 223 patients treated for 24 weeks. SETTING: Patients from 32 hospitals in Europe were enrolled throughout a 1-year period. PATIENTS: Adult human immunodeficiency virus type 1 (HIV-1)-positive,...
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