Article
Variable expression of RFC1 in human leukemia cell lines resistant to antifolates.
Cancer letters - 27 Feb 1998
Kobayashi H, Takemura Y, Ohnuma T
Abstract excerpt
The resistance to folate-based antifolates is associated with impaired function of the reduced folate carrier (RFC), one of the major routes of folate transport into cancer cells. To clarify the importance of RFC functions in the antifolate resistance, we have examined the expression of RFC1 and...
Topics
- Antimetabolites, Antineoplastic
- Biological Transport
- Carrier Proteins
- Drug Resistance, Neoplasm
- Folic Acid
- Folic Acid Antagonists
- Humans
- Leucovorin
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Membrane Proteins
- Membrane Transport Proteins
- Methotrexate
- Phenotype
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Quinazolines
- Tetrahydrofolate Dehydrogenase
- Thiophenes
- Tumor Cells, Cultured