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Article

Variable expression of RFC1 in human leukemia cell lines resistant to antifolates.

Cancer letters - 27 Feb 1998

Kobayashi H, Takemura Y, Ohnuma T

Abstract excerpt

The resistance to folate-based antifolates is associated with impaired function of the reduced folate carrier (RFC), one of the major routes of folate transport into cancer cells. To clarify the importance of RFC functions in the antifolate resistance, we have examined the expression of RFC1 and its phenotype as a folate transporter in human leukemia cell lines resistant to various antifolates. MOLT-3 cells...

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Source

Identifiers

PMID: 9500202
DOI: 10.1016/s0304-3835(97)00464-3

Genes

RFC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variable expression of RFC1 in human leukemia cell lines resistant to antifolates.PMID 9500202Read ↗

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