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Article

A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples.

Leukemia research - 1 Jul 2011

Pekova Sona, Mazal Oldrich, Cmejla Radek, Hardekopf David W, Plachy Radek, Zejskova Lenka, Haugvicova Renata, Jancuskova Tereza, Karas Michal, Koza Vladimir, Smolej Lukas, Bezdickova Ludmila, Kozak Tomas

Abstract excerpt

TP53 plays a pivotal role in the process of DNA repair and apoptosis. In 10-20% of patients with chronic lymphocytic leukemia (CLL), the TP53 pathway is affected. In this study, we analyzed the TP53 mutation status in 2435 consecutive CLL samples, including 1287 diagnostic samples and 1148 samples during follow-up, using FASAY (Functional Analysis of Separated Alleles in Yeast) and direct sequencing. In a cohort...

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Identifiers

PMID: 21232794
DOI: 10.1016/j.leukres.2010.12.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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