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Article

Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells.

The Journal of pathology - 1 Nov 2003

Emmerich Florian, Theurich Sebastian, Hummel Michael, Haeffker Antje, Vry Magnus S, Döhner Konstanze, Bommert Kurt, Stein Harald, Dörken Bernd

Abstract excerpt

The pathogenesis of Hodgkin lymphoma (HL) is still unclear. Previous investigations have demonstrated constitutive nuclear activity of the transcription factor NF kappa B (NF-kappaB) in Hodgkin/Reed-Sternberg (HRS) cells as an important prerequisite in protecting these cells from apoptosis. As a molecular mechanism leading to constitutive NF-kappaB activity in HRS cells, mutations of the NF-kappaB inhibitor I...

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PMID: 14595753
DOI: 10.1002/path.1454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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