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Article

Circumsporozoite protein genes of malaria parasites (Plasmodium spp.): evidence for positive selection on immunogenic regions.

Genetics - 1 Feb 1991

Hughes A L

Abstract excerpt

The circumsporozoite (CS) protein is a cell surface protein of the sporozoite, the stage of the life cycle of malaria parasites (Plasmodium spp.) that infects the vertebrate host. Analysis of DNA sequences supports the hypothesis that in Plasmodium falciparum, positive Darwinian selection favors diversity in the T-cell epitopes (peptides presented to T cells by host MHC molecules) of the CS protein. In gene...

Topics

Amino Acid Sequence
Animals
Antigens, Protozoan
Epitopes
Genes
Genetic Variation
Humans
Molecular Sequence Data
Plasmodium
Plasmodium berghei
Plasmodium falciparum
Plasmodium yoelii

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protozoan Proteins

Selection, Genetic

Sequence Homology, Nucleic Acid

Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 1706291
DOI: 10.1093/genetics/127.2.345
PMCID: PMC1204362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1706291-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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