Mutations with multiple independent origins in surface antigens mark the targets of biological selective pressure.

doi:10.1016/0165-2478(90)90085-5

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Article

Mutations with multiple independent origins in surface antigens mark the targets of biological selective pressure.

Immunology letters - 1 Aug 1990

McCutchan T F, Waters A P

Abstract excerpt

This manuscript documents the existence and importance of a small subset of mutations in Plasmodium falciparum genes that continually reoccur in separated populations. Here we describe how to identify recurrent mutations using a novel application of pre-existing computer programs designed to trac...

Topics

Animals
Antigens, Protozoan
Antigens, Surface
Genealogy and Heraldry
Mutation
Plasmodium falciparum
Polymorphism, Restriction Fragment Length
Protozoan Proteins
Selection, Genetic
Software

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