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Article

The p53 Pathway and Outcome among Patients with T1G3 Bladder Tumors

15 Oct 2006

Abstract excerpt

PURPOSE: The aim was to analyze Tp53 and HDM2 in T1G3 bladder tumors and to determine the prognostic value of their alterations. EXPERIMENTAL DESIGN: Tumors (n = 119) were extracted from a prospective study of 1,356 bladder cancers. Tp53 mutations (exons 4-9) were assessed by sequencing of PCR products. HDM2 dose was assessed by quantitative PCR. p53, HDM2, and the products of p53 target genes were analyzed by...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 17062677
DOI: 10.1158/1078-0432.ccr-06-0206

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