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Article

SNiPer-HD: improved genotype calling accuracy by an expectation-maximization algorithm for high-density SNP arrays.

Bioinformatics (Oxford, England) - 1 Jan 2007

Hua Jianping, Craig David W, Brun Marcel, Webster Jennifer, Zismann Victoria, Tembe Waibhav, Joshipura Keta, Huentelman Matthew J, Dougherty Edward R, Stephan Dietrich A

Abstract excerpt

MOTIVATION: The technology to genotype single nucleotide polymorphisms (SNPs) at extremely high densities provides for hypothesis-free genome-wide scans for common polymorphisms associated with complex disease. However, we find that some errors introduced by commonly employed genotyping algorithms may lead to inflation of false associations between markers and phenotype. RESULTS: We have developed a novel SNP...

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Identifiers

PMID: 17062589
DOI: 10.1093/bioinformatics/btl536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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