A novel simulation tool for low-coverage whole-genome sequencing using multivariate Gaussian mixture models.

Abstract excerpt

BACKGROUND: Low-coverage whole-genome sequencing (lcWGS) has emerged as a cost-effective and robust approach for population genomic studies. Despite its advantages, publicly available resources for large-scale lcWGS datasets remain limited. To our knowledge, there is yet a bioinformatics tool capable of directly simulating lcWGS datasets from variant call format (VCF) files. To address this gap, we developed a...

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