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Article

Sniper: improved SNP discovery by multiply mapping deep sequenced reads.

Genome biology - 20 Jun 2011

Simola Daniel F, Kim Junhyong

Abstract excerpt

SNP (single nucleotide polymorphism) discovery using next-generation sequencing data remains difficult primarily because of redundant genomic regions, such as interspersed repetitive elements and paralogous genes, present in all eukaryotic genomes. To address this problem, we developed Sniper, a novel multi-locus Bayesian probabilistic model and a computationally efficient algorithm that explicitly incorporates...

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Share to Genome, Human
Share to Genotyping Techniques
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Repetitive Sequences, Nucleic Acid

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Identifiers

PMID: 21689413
DOI: 10.1186/gb-2011-12-6-r55
PMCID: PMC3218843

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