Article
High-resolution array comparative genomic hybridization analysis reveals unanticipated complexity of genetic deficiencies on chromosome V in Caenorhabditis elegans.
Molecular genetics and genomics : MGG - 1 Jul 2009
Jones Martin R, Chua Shu Yi, O'Neil Nigel J, Johnsen Robert C, Rose Ann M, Baillie David L
Abstract excerpt
Genomic rearrangements are widely used in Caenorhabditis elegans research but many remain incompletely characterized at the physical level. We have used oligo-array comparative genomic analysis to assess the physical structure of 20 deficiencies and a single duplication of chromosome V. We find that while deletions internal to the chromosome appear simple in structure, terminal deletions are complex, containing...
Topics
- Animals
- Caenorhabditis elegans
- Chromosome Breakage
- Chromosome Deletion
- Chromosome Mapping
- Comparative Genomic Hybridization
- Crossing Over, Genetic
- Gene Rearrangement
- Genes, Helminth
- Genome, Helminth
- Models, Genetic
- Mutation