Article
C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice.
Proceedings of the National Academy of Sciences of the United States of America - 8 Feb 2011
Wang Yue-Ying, Zhao Li-Juan, Wu Chuan-Feng, Liu Ping, Shi Lin, Liang Yang, Xiong Shu-Min, Mi Jian-Qing, Chen Zhu, Ren Ruibao, Chen Sai-Juan
Abstract excerpt
The full-length AML1-ETO (AE) fusion gene resulting from t(8;21)(q22;q22) in human acute myeloid leukemia (AML) is not sufficient to induce leukemia in animals, suggesting that additional mutations are required for leukemogenesis. We and others have identified activating mutations of C-KIT in nearly half of patients with t(8;21) AML. To test the hypothesis that activating C-KIT mutations cooperate with AE to...
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