Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wild-type p53 is not a negative regulator of simian virus 40 DNA replication in infected monkey cells.

Journal of virology - 1 Feb 1993

von der Weth A, Deppert W

Abstract excerpt

To analyze the proposed growth-inhibitory function of wild-type p53, we compared simian virus 40 (SV40) DNA replication in primary rhesus monkey kidney (PRK) cells, which express wild-type p53, and in the established rhesus monkey kidney cell line LLC-MK2, which expresses a mutated p53 that does not complex with large T antigen. SV40 DNA replication proceeded identically in both cell types during the course of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to DNA Replication
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Gene Expression Regulation, Viral

Share to Genes, Suppressor

Share to Phenotype

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 8380470
DOI: 10.1128/JVI.67.2.886-893.1993
PMCID: PMC237442

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wild-type p53 is not a negative regulator of simian virus 40 DNA replication in infected monkey cells.PMID 8380470Read ↗

Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen.Semantic proximity Read ↗

Stable T-p53 complexes are not required for replication of simian virus 40 in culture or for enhanced phosphorylation of T antigen and p53.Semantic proximity Read ↗

Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation.Semantic proximity Read ↗

Simian virus 40 small-t antigen stimulates viral DNA replication in permissive monkey cells.Semantic proximity Read ↗

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replicationSemantic proximity Read ↗

Interaction of simian virus 40 large T-antigen with cellular DNA polymerase alpha: studies with various T-antigen mutants of SV40.Semantic proximity Read ↗

New Insights into the Mechanism of Inhibition of p53 by Simian Virus 40 Large T AntigenSemantic proximity Read ↗

In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes.Semantic proximity Read ↗

Potential Role for p53 in the Permissive Life Cycle of Human CytomegalovirusSemantic proximity Read ↗

Stabilization of the tumor suppressor p53 during cellular transformation by simian virus 40: influence of viral and cellular factors and biological consequences.Semantic proximity Read ↗

The kinetics of simian virus 40-induced progression of quiescent cells into S phase depend on four independent functions of large T antigenSemantic proximity Read ↗

Evidence against a Role for SV40 in Human MesotheliomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.