Article
Zinc is a mixed antagonist of homomeric rho 1 gamma-aminobutyric acid-activated channels.
Molecular pharmacology - 1 Mar 1995
Chang Y, Amin J, Weiss D S
Abstract excerpt
The transition metal Zn2+ is differentially distributed in the central nervous system, where it is proposed to be a neuromodulator. One of the documented effects of Zn2+ is the antagonism of gamma-aminobutyric acid (GABA)-mediated synaptic inhibition. This antagonism is presumed to result from a direct interaction of Zn2+ with the GABA receptor/ionophore complex, although the characteristics of Zn2+ sensitivity...
Topics
- Animals
- Binding Sites
- Binding, Competitive
- Drug Interactions
- Female
- GABA Antagonists
- Ion Channels
- Kinetics
- Macromolecular Substances
- Mutation
- Oocytes
- Receptors, GABA