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Article

NF-kappaB regulation of endothelial cell function during LPS-induced toxemia and cancer.

The Journal of clinical investigation - 1 Nov 2006

Kisseleva Tatiana, Song Li, Vorontchikhina Marina, Feirt Nikki, Kitajewski Jan, Schindler Christian

Abstract excerpt

The transcription factor NF-kappaB is an important regulator of homeostatic growth and inflammation. Although gene-targeting studies have revealed important roles for NF-kappaB, they have been complicated by component redundancy and lethal phenotypes. To examine the role of NF-kappaB in endothelial tissues, Tie2 promoter/enhancer-IkappaBalpha(S32A/S36A) transgenic mice were generated. These mice grew normally but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17053836
DOI: 10.1172/JCI27392
PMCID: PMC1616192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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