Article
Blockade of the nuclear factor-κB pathway in the endothelium prevents insulin resistance and prolongs life spans.
Circulation - 6 Mar 2012
Hasegawa Yutaka, Saito Tokuo, Ogihara Takehide, Ishigaki Yasushi, Yamada Tetsuya, Imai Junta, Uno Kenji, Gao Junhong, Kaneko Keizo, Shimosawa Tatsuo, Asano Tomoichiro, Fujita Toshiro, Oka Yoshitomo, Katagiri Hideki
Abstract excerpt
BACKGROUND: Nuclear factor-κB (NF-κB) signaling plays critical roles in physiological and pathological processes such as responses to inflammation and oxidative stress. METHODS AND RESULTS: To examine the role of endothelial NF-κB signaling in vivo, we generated transgenic mice expressing dominant-negative IκB under the Tie2 promoter/enhancer (E-DNIκB mice). These mice exhibited functional inhibition of NF-κB...
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