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Article

An unusual Dicer-like1 protein fuels the RNA interference pathway in Trypanosoma brucei.

RNA (New York, N.Y.) - 1 Dec 2006

Shi Huafang, Tschudi Christian, Ullu Elisabetta

Abstract excerpt

RNA interference (RNAi) is an evolutionarily conserved gene-silencing pathway that is triggered by double-stranded RNA (dsRNA). Central to this pathway are two ribonucleases: Dicer, a multidomain RNase III family enzyme that initiates RNAi by generating small interfering RNAs (siRNAs), and Argonaute or Slicer, an RNase H signature enzyme that affects cleavage of mRNA. Previous studies in the early diverging...

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Identifiers

PMID: 17053086
DOI: 10.1261/rna.246906
PMCID: PMC1664728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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