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Article

Selection and characterization of RNA interference-deficient trypanosomes impaired in target mRNA degradation.

Eukaryotic cell - 1 Dec 2004

Shi Huafang, Chamond Nathalie, Tschudi Christian, Ullu Elisabetta

Abstract excerpt

Genetic analysis of the RNA interference (RNAi) pathway in Trypanosoma brucei has so far revealed one essential component, namely, TbAGO1, encoding a member of the Argonaute protein family. To gain further insight into the RNAi mechanism and its biological significance, we selected RNAi-deficient trypanosomes by using repeated cycles of electroporation with alpha-tubulin double-stranded RNA, a treatment that...

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Source

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Identifiers

PMID: 15590819
DOI: 10.1128/EC.3.6.1445-1453.2004
PMCID: PMC539030

Genes

AGO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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