Article
Proinsulin is encoded by an RNA splice variant in human blood myeloid cells.
Proceedings of the National Academy of Sciences of the United States of America - 31 Oct 2006
Narendran Parth, Neale Alana M, Lee Bo Han, Ngui Katrina, Steptoe Raymond J, Morahan Grant, Madsen Ole, Dromey James A, Jensen Kent P, Harrison Leonard C
Abstract excerpt
Genes for peripheral tissue-restricted self-antigens are expressed in thymic and hematopoietic cells. In thymic medullary epithelial cells, self-antigen expression imposes selection on developing autoreactive T cells and regulates susceptibility to autoimmune disease in mouse models. Less is known about the role of self-antigen expression by hematopoietic cells. Here we demonstrate that one of the endocrine...
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