Article
Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in humans.
Diabetologia - 1 Dec 2013
de Jong V Martijn, Abreu Joana R F, Verrijn Stuart Annemarie A, van der Slik Arno R, Verhaeghen Katrijn, Engelse Marten A, Blom Bianca, Staal Frank J T, Gorus Frans K, Roep Bart O
Abstract excerpt
AIMS/HYPOTHESIS: Thymic expression of self-antigens during T-lymphocyte development is believed to be crucial for preventing autoimmunity. It has been suggested that G6PC2, the gene encoding islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), is differentially spliced between pancreatic beta cells and the thymus. This may contribute to incomplete elimination of IGRP-specific T...
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