Article
Enhanced natural-killer cell and erythropoietic activities in VEGF-A-overexpressing mice delay F-MuLV-induced erythroleukemia.
Blood - 1 Mar 2007
Cervi David, Shaked Yuval, Haeri Mehran, Usenko Tatiana, Lee Christina R, Haigh Jody J, Nagy Andras, Kerbel Robert S, Yefenof Eitan, Ben-David Yaacov
Abstract excerpt
We have previously reported that VEGF-A, in combination with MCP-5, contributes to leukemia progression within the splenic microenvironment of mice infected with F-MuLV. To study the influence of constitutively elevated VEGF-A levels on the progression of erythroleukemia, mice heterozygous for a VEGF-A "hypermorphic" allele (Vegfhi/+) were inoculated with F-MuLV. Unexpectedly, a significant delay in...
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