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Article

Critical requirement of VEGF-C in transition to fetal erythropoiesis

24 Jun 2016

Abstract excerpt

Vascular endothelial growth factor C (VEGF-C) is a major driver of lymphangiogenesis in embryos and adults. Vegfc gene deletion in mouse embryos results in failure of lymphangiogenesis, fluid accumulation in tissues, and lethality. The VEGF-C receptors VEGFR3 and VEGFR2 are required for embryonic blood vessel formation. The related VEGF is essential for both blood vessel formation and embryonic hematopoiesis,...

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PMID: 27343251
DOI: 10.1182/blood-2015-12-687970

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