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VEGF-A165 augments erythropoietic development from human embryonic stem cells

9 Dec 2003

Abstract excerpt

Combinations of hematopoietic cytokines and the ventral mesoderm inducer BMP-4 have recently been shown to augment hematopoietic cell fate of human embryonic stem cells (hESCs) during embryoid body (EB) development. However, factors capable of regulating lineage commitment of hESC-derived hematopoiesis have yet to be reported. Here we show that vascular endothelial growth factor (VEGF-A165) selectively promotes...

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PMID: 14656883
DOI: 10.1182/blood-2003-07-2563

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