Article
DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia.
The Journal of biological chemistry - 26 Dec 2008
Bogacheva Olga, Bogachev Oleg, Menon Madhu, Dev Arvind, Houde Estelle, Valoret Elizabeth I, Prosser Haydn M, Creasy Caretha L, Pickering Susan J, Grau Evelyn, Rance Kim, Livi George P, Karur Vinit, Erickson-Miller Connie L, Wojchowski Don M
Abstract excerpt
During anemia erythropoiesis is bolstered by several factors including KIT ligand, oncostatin-M, glucocorticoids, and erythropoietin. Less is understood concerning factors that limit this process. Experiments performed using dual-specificity tyrosine-regulated kinase-3 (DYRK3) knock-out and transgenic mice reveal that erythropoiesis is attenuated selectively during anemia. DYRK3 is restricted to erythroid...
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