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Article

Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly.

PLoS pathogens - 1 Jan 2012

Neveu Gregory, Barouch-Bentov Rina, Ziv-Av Amotz, Gerber Doron, Jacob Yves, Einav Shirit

Abstract excerpt

Novel therapies are urgently needed against hepatitis C virus infection (HCV), a major global health problem. The current model of infectious virus production suggests that HCV virions are assembled on or near the surface of lipid droplets, acquire their envelope at the ER, and egress through the secretory pathway. The mechanisms of HCV assembly and particularly the role of viral-host protein-protein interactions...

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Share to Adaptor Protein Complex 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22916011
DOI: 10.1371/journal.ppat.1002845
PMCID: PMC3420927

Genes

AAK1
GAK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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