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Article

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.

The Journal of biological chemistry - 19 Nov 2004

Benjannet Suzanne, Rhainds David, Essalmani Rachid, Mayne Janice, Wickham Louise, Jin Weijun, Asselin Marie-Claude, Hamelin Josée, Varret Mathilde, Allard Delphine, Trillard Mélanie, Abifadel Marianne, Tebon Angie, Attie Alan D, Rader Daniel J, Boileau Catherine, Brissette Louise, Chrétien Michel, Prat Annik, Seidah Nabil G

Abstract excerpt

The discovery of autosomal dominant hypercholesterolemic patients with mutations in the PCSK9 gene, encoding the proprotein convertase NARC-1, resulting in the missense mutations suggested a role in low density lipoprotein (LDL) metabolism. We show that the endoplasmic reticulum-localized proNARC-1 to NARC-1 zymogen conversion is Ca2+-independent and that within the zymogen autocatalytic processing site SSVFAQ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15358785
DOI: 10.1074/jbc.M409699200

Genes

LDLR
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.PMID 15358785Read ↗

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