Article
The potential tumour suppressor role for caspase-9 (CASP9) in the childhood malignancy, neuroblastoma.
European journal of cancer (Oxford, England : 1990) - 1 Nov 2001
Catchpoole D R, Lock R B
Abstract excerpt
The clinical aggressiveness of neuroblastoma, a childhood embryonal tumour of neuroectodermal cells derived from the neural crest, is considered to be dictated by the competitive interactions between cell proliferation, differentiation and apoptosis. Caspase-9 is a central effector enzyme in the apoptotic mechanism. Recent studies with caspase-9 (CASP9) knockout mice indicate a primary defect in the brain caused...
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