Article
[Establishment of hypertrophic chondrocytes-specific Cre transgenic mice].
Yi chuan = Hereditas - 1 Jan 2009
Hou Ning, Yang Guan, Fan Xiong-Wei, Wu Xiu-Shan, Yang Xiao
Abstract excerpt
Hypertrophic chondrocytes, which are the terminally differentiated form of chondrocytes, play a key role in endochondral ossification. In order to investigate the functions of hypertrophic chondrocytes during bone development, we generated a new transgenic line expressing Cre recombinase under the control of a 8.2 kb mouse type X collagen gene promoter (Col10a1(8.2)-Cre). Microinjection was employed to introduce...
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